Resuscitation fluids

Resuscitation fluids.

From the University of New South Wales, the Division of Critical Care and Trauma, George Institute for Global Health, and the Department of Intensive Care Medicine, St. George Hospital — all in Sydney (J.A.M.); and the National Institute for Health Research, University College London Hospitals Biomedical Research Centre, London (M.G.M.). Address reprint requests to Dr. Myburgh at the Department...

Hemoglobin-based oxygen-carrying resuscitation fluids.

Anti-inflammatory adjuvant in resuscitation fluids improves survival in hemorrhage.

OBJECTIVES Severe hemorrhage is a common cause of death despite the recent advances in critical care. Conventional resuscitation fluids are designed to reestablish tissue perfusion, but they fail to prevent lethal inflammatory responses. Our previous studies indicate that ethyl pyruvate (EP) inhibits tumor necrosis factor (TNF) production from macrophages. Here, we analyze whether EP can provid...

Effects of colloidal resuscitation fluids on reticuloendothelial function and resistance to infection after hemorrhage.

The effects of three resuscitation fluids, hydroxyethyl starch (HES), Haemaccel, and fresh autologous blood, on reticuloendothelial system phagocytic and catabolic functions and resistance to infection after 40% hemorrhages in BALB/c mice were studied. The mice, anesthetized with isoflurane, were bled over a 10-min period, left hypovolemic for 30 min, and then resuscitated with their shed blood...

Higher fluids in the first three hours of sepsis resuscitation? Too soon to conclude.

Th e authors used electronic medical records (EMRs) to identify patients with severe sepsis and septic shock. “Sepsis onset time” was determined by fl uidresistant hypotension, vasopressor use, or a lactate level . 4 mmol/L. 1 Th e reliability and validity of the outcome data in EMR-based interventional studies depend on the accuracy of data collection, entry, and storage. A study conducted on ...